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2021

CTCF is a barrier for 2C-like reprogramming

Olbrich, T., Vega-Sendino, M., Tillo, D., Wu, W., Zolnerowich, N., Pavani, R., Tran, A.D., Domingo, C.N., Franco, M., Markiewicz-Potoczny, M., Pegoraro, G., Fitzgerald, P.C., Kruhlak, M.J., Lazzerini-Denchi, E., Nora, E.P., Nussenzweig, A., Ruiz, S.

PubMed Link

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Wang, Y., Salvucci, O., Ohnuki, H., Tran, A.D., Ha, T., Feng, J.X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., Tosato, G.

PubMed Link

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Baik, J.Y., Liu, Z., Jiao, D., Kwon, H.J., Kadigamuwa, C., Choe, M., Lake, R., Kruhlak, M.J., Tandon, M., Cai, Z., Choksi, S., Liu, Z.G.

PubMed Link

IDH1 mutations induce organelle defects via dysregulated phospholipids

Lita, A., Pliss, A., Kuzmin, A., Yamasaki, T., Zhang, L., Dowdy, T., Burks, C., de Val, N., Celiku, O., Ruiz-Rodado, V., Nicoli, E.R., Kruhlak, M.J., Andersson, T., Das, S., Yang, C., Schmitt, R., Herold-Mende, C., Gilbert M.R., Prasad, P.N., Larion, M.

PubMed Link

Thyroid hormone receptor alpha mutations cause heart defects in zebrafish

Han, C.R., Wang, H., Hoffman, V., Zerfas, P., Kruhlak, M.J., Cheng S.Y

PubMed Link

Phase separation of the Cep63-Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes

Ahn, J., Park, J.E., Meng, L., Zhang, L., Kim, T.S. Kruhlak, M.J., Kim, B.Y., Lee, K.S.

PubMed Link

2020

53BP1 enforces distinct pre- and post-resection blocks on homologous recombination

Callen, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L.C., Byrum, A.K., Mendez-Dorantes, C., Martinez, P., Canela, A., Maman, Y., Day, A., Kruhlak, M.J., Blasco, M.A., Stark, J.M., Mosammaparast, N., McKinnon, P.J., Nussenzweig, A.

PubMed Link

2019

Dysfunction and stemness of tumor-infiltrating T cells are triggered by a common mechanism

Vodnala, S.K., Eli, R., Kishton, R.J., Sukumar, M., Yamamoto, T.N., Ha, N., Lee, P., Shin, M.H, Patel, S., Yu, Z., Palmer, D., Kruhlak, M.J., Huang, J., Roychoudnuri, R., Finkel, T., Klebanoff, C.A., Restifo, N. P.

PubMed Link