NCI Optical Microscopy Laboratories

Software & Techniques

Scientific Publications

Publications (2015-present)

1. Chen WY, Liu SY, Chang YS, Yin JJ, Yeh HL, Mouhieddine TH, Hadadeh O, Abou-Kheir W, Liu YN. MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer. Oncotarget 1:441-57 (2015).

2. Siu MK, Tsai YC, Chang YS, Yin JJ, Suau F, Chen WY, Liu YN. Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway. Oncogene 36:4767-76 (2015).

3. Poruchynsky MS, Komlodi-Pasztor E, Trostel S, Wilkerson J, Regairaz M, Pommier Y, Zhang X, Kumar Maity T, Robey R, Burotto M, Sackett D, Guha U, Fojo AT. Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins. Proc Natl Acad Sci 5:1571-6 (2015).

4. Divi KV, Ward Y, Poirier MC, Olivero OA. Use of Ciliogenesis to Detect Aneugens: The Role of Primary Cilia. Curr Protoc Toxicol 13:1-8 (2015).

5. Chang YS, Chen WY, Yin JJ, Tillman HS, Huang J, Liu YN. EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1. Cancer Res 15:3077-86 (2015).

6. Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K. Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. Cell Rep 10:2147-58 (2015).

7. Liu YN, Yin J, Barrett B, Sheppard-Tillman H, Li D, Casey OM, Fang L, Hynes PG, Ameri AH, Kelly K. Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis. Mol Cell Biol 11:1940-51 (2015).

8. Zhang L, Boufraqech M, Lake R, Kebebew E. Carfilzomib potentiates CUDC-101-induced apoptosis in anaplastic thyroid cancer. Oncotarget 10.18632 (2016).

9. Staunton JR, Vieira W, Fung KL, Lake R, Devine A, Tanner K. Mechanical properties of the tumor stromal microenvironment probed ex vivo by in situ-calibrated optical trap-based active microrheology. Cell Mol Bioeng. 9(3):398-417 (2016).

10. Cai Z, Zhang A, Choksi S, Li T, Zhang X, Liu ZG. Activation of cell surface proteases promotes necroptosis, inflammation, and cell migration. Cell Res. Aug; 26(8): 886–900 (2016).

11. Lee RM, Stuelten CH, Parent CA,Losert W. Collective cell migration over long time scales reveals distinct phenotypes. Converg Sci Phys Oncol. Jun;2(2) (2016).

12. Xu Q, Choksi S, Qu J, Jang J, Choe M, Banfi B, Engelhardt JF, Liu ZG. NADPH oxidases are essential for macrophage differentiation. J Biol Chem. Sep 16;291(38):20030-41 (2016).

13. Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K. Androgen Deprivation Leads to Increased Carbohydrate Metabolism and Hexokinase 2 Mediated Survival in Pten/Tp53 Deficient Prostate Cancer. Oncogene (4):525-533. (2017).

14. Xu, Q, Jitkaew S, Choksi S, Kadigamuwa C, Choe M, Jang J, Liu C, Liu ZG. The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited. Nat Commun. 4;8(1):425 (2017).

15. Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N, Altan-Bonnet G. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. 66(5):635-647 (2017).

16. Jackson S, ElAli A, Virgintino D, Gilbert MR. Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer’s disease. Neuro Oncol. 19(9):1173-1182. (2017).

17. Wang T, Hamilla S, Cam M, Aranda-Espinoza H, Mili S. Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration. Nat Commun. 8(1):896 (2017).

18. Pan H, Jansson KH, Beshiri ML, Yin J, Fang L, Agarwal S, Nguyen H, Corey E, Zhang Y, Liu J, Fan H, Lin H, Kelly K. Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer. Oncotarget. 8(44):77181-77 (2017).

19. Beshiri ML, Tice CM, Tran C, Nguyen HM, Sowalsky AG, Agarwal S, Jansson KH, Yang Q, McGowen KM, Yin J, Alilin AN, Karzai FH, Dahut WL, Corey E, Kelly K. A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening. Clin Cancer Res. 24(17):4332-4345 (2018).

20. Pan H, Lu LY, Wang XQ, Li BX, Kelly K, Lin HS. Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN-/-/p53-/- Prostate Cancer Cells In Vitro and Ex Vivo. Chin J Integr Med. 24(2):109-116 (2018).

21. Ward Y, Lake R, Faraji F, Tillman H, Yin JJ, Sperger J, Martin PL, Hunter K, Lang J, Kelly K. CD97 on Tumor Cells Binds Platelets and Mediates Bidirectional Signaling to Promote Transendothelial Migration and Metastasis. Cell Rep. 23(3):808-822 (2018).

22. Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey Y, Cawley J, Tice CM, Yin J, McKnight C, Klummp-Thomas C, Zhang X, Guha R, Hoover S, Simpson RM, Nguyen HM, Corey E, Thomas CJ, Proia DA, Kelly K. High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer. Sci Rep. 8(1):17239 (2019).

23. Paul CD, Devine A, Bishop K, Xu Q, Wulftange WJ, Burr H, Daly KM, Lewis C, Green DS, Staunton JR, Choksi S, Liu ZG, Sood R, Tanner K. Human macrophages survive and adopt activated genotypes in living zebrafish. Sci Rep. 9(1):1759 (2019).

24. Paul CD, Hruska A, Staunton JR, Burr HA, Daly KM, Kim J, Jiang N, Tanner K. Probing cellular response to topography in three dimensions. Biomaterials. 197:101-118 (2019).