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NCI Optical Microscopy Laboratory

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2021

CTCF is a barrier for 2C-like reprogramming

Olbrich, T., Vega-Sendino, M., Tillo, D., Wu, W., Zolnerowich, N., Pavani, R., Tran, A.D., Domingo, C.N., Franco, M., Markiewicz-Potoczny, M., Pegoraro, G., Fitzgerald, P.C., Kruhlak, M.J., Lazzerini-Denchi, E., Nora, E.P., Nussenzweig, A., Ruiz, S.

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Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Wang, Y., Salvucci, O., Ohnuki, H., Tran, A.D., Ha, T., Feng, J.X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., Tosato, G.

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ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Baik, J.Y., Liu, Z., Jiao, D., Kwon, H.J., Kadigamuwa, C., Choe, M., Lake, R., Kruhlak, M.J., Tandon, M., Cai, Z., Choksi, S., Liu, Z.G.

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IDH1 mutations induce organelle defects via dysregulated phospholipids

Lita, A., Pliss, A., Kuzmin, A., Yamasaki, T., Zhang, L., Dowdy, T., Burks, C., de Val, N., Celiku, O., Ruiz-Rodado, V., Nicoli, E.R., Kruhlak, M.J., Andersson, T., Das, S., Yang, C., Schmitt, R., Herold-Mende, C., Gilbert M.R., Prasad, P.N., Larion, M.

PubMed Link

Thyroid hormone receptor alpha mutations cause heart defects in zebrafish

Han, C.R., Wang, H., Hoffman, V., Zerfas, P., Kruhlak, M.J., Cheng S.Y

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Phase separation of the Cep63-Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes

Ahn, J., Park, J.E., Meng, L., Zhang, L., Kim, T.S. Kruhlak, M.J., Kim, B.Y., Lee, K.S.

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2020

53BP1 enforces distinct pre- and post-resection blocks on homologous recombination

Callen, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L.C., Byrum, A.K., Mendez-Dorantes, C., Martinez, P., Canela, A., Maman, Y., Day, A., Kruhlak, M.J., Blasco, M.A., Stark, J.M., Mosammaparast, N., McKinnon, P.J., Nussenzweig, A.

PubMed Link

2019

Dysfunction and stemness of tumor-infiltrating T cells are triggered by a common mechanism

Vodnala, S.K., Eli, R., Kishton, R.J., Sukumar, M., Yamamoto, T.N., Ha, N., Lee, P., Shin, M.H, Patel, S., Yu, Z., Palmer, D., Kruhlak, M.J., Huang, J., Roychoudnuri, R., Finkel, T., Klebanoff, C.A., Restifo, N. P.

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