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NCI Optical Microscopy Laboratory

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Publications

1. Patino-Lopez, G., Aravind, L., Dong, X., Kruhlak, M.J., Ostap, E.M., and Shaw, S.: Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH). Journal of Biological Chemistry. 285:8675-8686, 2010.

2. Bhatia, S., Sun, K., Almo, S.C., Nathenson, S.G., Hodes, R.J. Dynamic equilibrium of B7-1 dimers and monomers differentially affects immunological synapse formation and T cell activation in response to TCR/CD28 stimulation. Journal of Immunology. 184:1821-1828, 2010.

3. Majerciak, V., Kruhlak, M., Dagur, P.K., McCoy J.P.Jr., and Zheng, Z.M.: Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression. Journal of Biological Chemistry. 285:11297-11307, 2010.

4. Katragkou, A., Kruhlak, M.J., Simitsopoulou, M., Chatzimoschou, A., Taparkou, A., Cotton, C.J., Paliogianni, F., Diza-Mataftsi, E., Tsantali, C., Walsh, T.J., and Roilides, E.: Interactions between human phagocytes and Candida albicans biofilms alone and in combination with antifungal agents. Journal of Infectious Diseases. 201:1941-1949, 2010.

5. Chiang, Y.J., Calado, R.T., Hathcock, K.S., Lansdorp, P.M., Young, N.S., Hodes, R.J. Telomere length is inherited with resetting of the telomere set-point. PNAS. 107:10148-10153, 2010.

6. Santos, M.A., Huen, M.S., Jankovic, M., Chen, H.T., Lopez-Contreras, A.J., Klein, I.A., Wong, N., Barbancho, J.L., Fernandez-Capetillo, O., Nussenzweig, M.C., Chen, J., Nussenzweig, A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. Journal of Experimental Medicine. 207:973-981, 2010.

7. Nakata, H., Kruhlak, M., Kamata, W., Ogata-Aoki, H., Li, J., Maeda, K., Ghosh, A.K., and Mitsuya, H.: Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions. Antiviral Therapy. 15:321-331, 2010.

8. Walseng, E., Furuta, K., Bosch, B., Weih, K.A., Matsuki, Y., Bakke, O., Ishido, S., Roche, P.A. Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells. PNAS. 107:20465-20470, 2010.

9. Daniel, J.A., Santos, M.A., Wang, Z., Zang, C., Schwab, K.R., Jankovic, M., Filsuf, D., Chen, H.T., Gazumyan, A., Yamane, A., Cho, Y.W., Sun, H.W., Ge, K., Peng, W., Nussenzweig, A. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science. 329:917-923, 2010.

10. Walseng, E., Furuta, K., Goldszmid, R.S., Weih, K.A., Sher, A., Roche, P.A. Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus. Journal of Biological Chemistry. 285:41749-41754, 2010.

11. Langer, H.F., Chung, K.J., Orlova, V.V., Choi, E.Y., Kaul, S., Kruhlak, M.J., Alatsatianos, M., Deangelis, R.A., Roche P.A., Magotti, P., Li, X., Economopoulou, M., Rafail, S., Lambris, J.D., and Chavakis, T. Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis. Blood. 116:4395-4403, 2010.

12. Majerciak, V., Uranishi, H., Kruhlak, M., Pilkington, G.R., Massimelli, M.J., Bear, J., Pavlakis, G.N., Felber, B.K., and Zheng, Z.M. Kaposi’s sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofators RBM15 and OTT3 to promote expression of viral ORF59.Journal of Virology. 85:1528-1540, 2011.

13. Rui, L., Emre, N.C., Kruhlak, M.J., Chung, H.J., Steidl, C., Slack, G., Wright, G.W., Lenz, G., Ngo, V.N., Shaffer, A.L., Xu, W., Zhao, H., Yang, Y., Lamy, L., Davis, R.E., Xiao, W., Powell, J., Maloney, D. Thomas, C.J., Möller, P., Rosenwald, A., Ott, G., Muller-Hermelink, H.K., Savage, K., Connors, J.M., Rimsza, L.M., Campo, E., Jaffe, E.S., Delabie, J., Smeland, E.B., Weisenburger, D.D., Chan, W.C., Gascoyne, R.D., Levens, D., and Staudt, L.M. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell. 18:590-605, 2011.

14. Jelinek, I., Leonard, J.N., Price, G.E., Brown, K.N., Meyer-Manlapat, A., Goldsmith, P.K., Wang, Y., Venzon, D., Epstein, S.L., Segal, D.M. TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dentritic cell cross-presentation, CTL responses, and antiviral protection. Journal of Immunology. 186:2422-2429, 2011.

15. Kang, J.G., Pripuzova, N., Majerciak, V., Kruhlak, M., Le, S.Y., and Zheng, Z.M. Kaposi’s sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression. Journal of Virology. 85:2620-2630, 2011.

16. Kang, J.G., Majerciak, V., uldrick, T.S., Wang, X., Kruhlak, M., Yarchoan, R., and Zheng, Z.M. Kaposi’s sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation. Journal of Pathology. 225:378-389, 2011.

17. Lonsdorf, A.S., Kramer, B.F., Fahrleitner, M., Schonberger, T., Gnerlich, S., Ring, S., Gehring, S., Schneider, S.W., Kruhlak, M.J., Meuth, S.G. Nieswandt, B., Gawaz, M., Enk, A.H., and Langer, H.F. Engagement of aIIbß3 (GPIIb/IIIa) with avß3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. Journal of Biological Chemistry. 287:2168-2178, 2012.

18. Liu, Y., Belkina, N.V., Park, C., Nambiar, R., Loughhead, S.M., Patino-Lopez, G., Ben-Aissa, K., Hao, J.J., Kruhlak, M.J., Qi, H., von Andrian, U.H., Kehrl, J.H., Tyska, M.J., and Shaw, S. Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice. Blood. 119:445-453, 2012.

19. Tai, X., Van Laethem, F., Pobezinsky, L., Guinter, T., Sharrow, S.O., Adams, A., Granger, L., Kruhlak, M., Lindsten, T., Thompson, C.B., Feigenbaum, L., and Singer, A. Basis of CTLA-4 function in regulatory and conventional CD4+ T cells. Blood. 119:5155-5163, 2012.

20. Ben-Aissa, K., Patino-Lopez, G., Blekina, N.V., Maniti, O., Rosales, T., Hao, J.J., Kruhlak, M.J., Knutson, J.R., Picart, C., and Shaw, S. Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an auto-inhibitory linker. Journal of Biological Chemistry. 287:16311-16323, 2012.

21. Langer, H.F., Choi, E.Y., Zhou, H., Schleicher, R., Chung, K.J., Tang, Z., Gobel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C., Bhatia, S., Kruhlak, M.J., Rose, J.W., Burns, J.B., Hill, K.E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K.G., Wang, Y., Simon, D.I., Nieswandt, B., Lambris, J.D., Li, X., Meuth, S.G., Kubes, P., Chavakis, T. Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circulation Research. 110:1202-1210, 2012.

22. Sousa, A.A., Morgan, J.T., Brown, P.H., Adams, A., Jayasekara, M.P., Zhang, G., Ackerson, C.J., Kruhlak, M.J., Leapman, R.D. Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles. Small. 8:2277-2286, 2012.

23. Muller, J.R., Waldmann, T.A., Kruhlak, M.J., Dubois, S. Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Ra in human monocytes and dendritic cells. Journal of Biological Chemistry. 287:40328-40338, 2012.

24. Gaiser, M.R., Lammermann, T., Feng, X., Igyarto, B.Z., Kaplan, D.H., Tessarollo, L., Germain, R.N., Udey, M.C. Cancer-associated epithelial cell adhesion molecule (EpCAM;CD326) enables epidermal Langerhans cell motility and migration in vivo. PNAS. 109:E889-E897, 2012.

25. Furuta, K., Ishido, S., Roche, P.A. Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells. PNAS. 109:19380-19385, 2012.

26. Devaiah, B.N., Singer, D.S. Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation. Journal of Biological Chemistry. 287:38755-38766, 2012.

28. Devaiah, B.N., Lewis, B.A., Cherman, N., Hewitt, M.C., Albrecht, B.K., Robey, P.G., Ozato, K., Sims, R.J. 3rd, Singer, D.S. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. PNAS. 109:6927-6932, 2012.

29. Chiang, Y.J., Difilippantonio, M.J., Tessarollo, L., Morse, H.C., Hodes, R.J. Exon1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomas. PLoS One. 7:e49305, 2012.

30. Massimelli, M.J., Majerciak, V., Kruhlak, M., Zheng, Z. Interplay between PABPC1 and KSHV ORF57 in accumulation of PAN, a viral lncRNA. Journal of Virology. 87:243-256, 2013.

31. Mandal, S., Mandal, A., Johansson, H.E., Orjalo, A.V., Park, M.H. Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. PNAS. 110:2169-2174, 2013.

32. Tai, X., Erman, B., Alag, A., Mu, J., Kimura, M., Katz, G., Guinter, T., McCaughtry, T., Etzensperger, R., Feigenbaum, L., Singer, D.S., Singer, A. Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity. 38:1116-1128, 2013.

33. Bowen, S., Wangsa, D., Ried, T., Livak, F., Hodes, R.J. Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes. Nucleic Acids Research. 41:4535-4548, 2013.

34. Tinsley, K.W., Hong, C., Luckey, M.A., Park, J.Y., Kim, G.Y., Yoon, H.W., Keller, H.R., Sacks, A.J., Feigenbaum, L., Park, J.H. Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus. Blood. 122:2358-2368, 2013.

35. Sousa, A.A., Kruhlak, M.J. Introduction: nanoimaging techniques in biology. Methods in Molecular Biology. 950:1-10, 2013.

36. Kruhlak, M.J. Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus. Methods in Molecular Biology. 950:397-416, 2013.

37. Bosch, B., Heipertz, E.L., Drake, J. R., Roche, P.A. Major histocompatibility complex (MHC) class II-peptide complexes arrive at the plasma membrane in cholesterol-rich microclusters. Journal of Biological Chemistry. 288:13236-13242, 2013.

38. Bosch, B., Berger, A.C., Khandelwal, S., Heipertz, E.L., Scharf, B., Santambrogio, L., Roche, P.A. Disruption of multivesicular body vesicles does not affect major histocompatibility complex (MHC) class II-peptide complex formation and antigen presentation by dendritic cells. Journal of Biological Chemistry. 288:24286-24292, 2013.

39. Hathcock, K.S., Bowen, S., Livak, F., Hodes, R.J. ATM influences the efficiency of TCRß rearrangement, subsequent TCRß-dependent T cell development, and generation of the pre-selection TCRß CDR3 repertoire. PLoS One. 8:e62188, 2013.

40. Lamy, L., Ngo, V.N., Emre, N.C., Shaffer, A.L., Yang, Y., Tian, E., Nair, V., Kruhlak, M.J., Zingone, A., Landgren, O., Staudt, L.M. Control of autophagic cell death by caspase-10 in multiple myeloma. Cancer Cell. 23:435-449, 2013.

41. Callen, E., Di Virgilio, M., Kruhlak, M.J., Nieto-Soler, M., Wong, N., Chen, H.T., Faryabi, R.B., Polato, F., Santos, M., Starnes, L.M., Wesemann, D.R., Lee, J.E., Tubbs, A., Sleckman, B.P., Daniel, J.A., Ge, K., Alt, F.W., Fernandez-Capetillo, O., Nussenzweig, M.C., Nussenzweig, A. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153:1266-1280, 2013.