Publications

Gujar V, Furusawa T, Sharma S, Boateng F, Li H, Achour C, Taniyama D, Kruhlak M, Pommier Y, Oberdoerffer S, Stracker TH, Weyemi U. Peroxiredoxin 1 safeguards the nucleolar genome from oxidative damage. Sci Adv. 2026 Sep 11;12(37):eaed4161. doi: 10.1126/sciadv.aed4161. Epub 2026 Sep 9. PMCID: PMC13557071. PMID: 42715307 Free PMC article.

Wang S, Yan H, Mondal P, Ayaz G, Yang HH, Kim YI, Tran AD, Kruhlak MJ, du Bois W, Lee MP, Huang J. Epigenetic Repression of Type I Interferon Signaling by RUNX2 Drives Immune Checkpoint Blockade Resistance in Osteosarcoma. Cancer Res. 2026 Sep 1. doi: 10.1158/0008-5472.CAN-25-3970. PMID: 42678247

Tabe C, Kumar R, Huang Y, Kruhlak MJ, Sharma AK, Shrestha RL, Thomas A. Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer. Cancer Res Commun. 2026 Sep 1;6(9):2110-2125. doi: 10.1158/2767-9764.CRC-26-0560. PMCID: PMC13555252. PMID: 42647139 Free PMC article.

Ramos-León F, Altouma V, Goldberg P, Ibrahim AM, D'Atri D, Machinandiarena F, Verdi V, Kruhlak MJ, Missiakas DM, Davis KM, Ramamurthi KS. Orthogonal cell division mediated by PcdA organizes surface virulence factors to drive staphylococcal abscess community formation. Cell Rep. 2026 Aug 17;45(8):117861. doi: 10.1016/j.celrep.2026.117861. Epub ahead of print. PMCID: PMC13573194. PMID: 42606939 Free PMC article.

Tang B, Minin J, Gonzalez VM, Khan ZZ, Gaines AR, Raviv Y, Yang YA, Carney CP, Millman ZG, Grun D, Pineda CM, Sharma A, Esposito D, Yan H, Huang J, Tran AD, Kruhlak M, Yang HH, Lee MP, Wakefield LM. Cancer stem cells are hyper-responsive sensors of the tumour microenvironment and regulate metastasis dynamics through YAP/TAZ. Nat Cell Biol. 2026 Aug;28(8):1728-1741. doi: 10.1038/s41556-026-02013-8. Epub 2026 Jul 27. PMCID: PMC13457095. PMID: 42509263 Free PMC article.

Carey GI, Vega-Sendino M, Tillo D, Hoelscher SC, Khan A, Taukulis I, Olbrich T, Saykali B, Tran AD, Soni B, Lee Fong A, Mikolaj M, Harned A, Narayan K, Kruhlak MJ, Kelly M, Liu NQ, de Wit E, Ruiz S. Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner. EMBO J. 2026 Aug;45(16):5657-5688. doi: 10.1038/s44318-026-00853-6. Epub 2026 Jul 9. PMCID: PMC13484482. PMID: 42426342 Free PMC article.

Feng JX, Durkin ME, Yang MT, Li L, Lake R, Li C, Livak F, Tessarollo L, Kruhlak M, Lowy DR, Tosato G. Role of endothelial Dlc1 in embryonic vascular development and adult bone marrow hematopoiesis. Leukemia. 2026 Aug;40(8):1708-1720. doi: 10.1038/s41375-026-03013-1. Epub 2026 Jun 25. PMCID: PMC13421314. PMID: 42350604 Free PMC article.

Kim O, Jung J, Sathe S, Yu G, Sergi Z, Li Q, Lu P, Zhang M, Hsia RC, Kruhlak MJ, Chari R, Wang H, Tran B, Holewinski RJ, Chan M, Andresson T, Liu ZG, Graves LM, Gujral TS, Iwanowicz EJ, Wu J. Targeting mitochondrial protease in diffuse gliomas. Mol Cancer Ther. 2026 Jul 14. doi: 10.1158/1535-7163.MCT-26-0156. PMID: 42442344

Kang SWS, Brown LA, Miller CB, Barrows KM, Golino JL, Liu H, Cultraro CM, Feliciano D, Cornelius-Muwanuzi MB, Remmert K, Hernandez JM, Tran AD, Kruhlak M, Lobanov A, Cam M, Porat-Shliom N. PLIN5 phosphorylation orchestrates mitochondria lipid-droplet coupling to control hepatic lipid flux and steatosis. Nat Metab. 2026 Mar;8(3):587-603. doi: 10.1038/s42255-026-01476-1. Epub 2026 Mar 23. PMCID: PMC13031124. PMID: 41872512 Free PMC article.

Saykali B, Tran AD, Kruhlak MJ, Ruiz S. Protocol for imaging and quantifying single-cell CDK activity levels during early mouse embryonic development by time-lapse microscopy. STAR Protoc. 2025 Sep 19;6(3):104065. doi: 10.1016/j.xpro.2025.104065. Epub 2025 Sep 8. PMCID: PMC12451177. PMID: 40924577 Free PMC article.

Liman N, Li C, Luckey MA, Keller HR, Li J, Hajjar W, Wisniewski J, Kruhlak M, Lazarevic V, Park JH. Integrin CD103 reveals a distinct developmental pathway of autoreactive thymocytes in TCR transgenic mice. Nat Commun. 2025 Jul 18;16(1):6627. doi: 10.1038/s41467-025-61922-8. PMCID: PMC12274481. PMID: 40681578 Free PMC article.

Saykali B, Tran AD, Cornwell JA, Caldwell MA, Sangsari PR, Morgan NY, Kruhlak MJ, Cappell SD, Ruiz S. Lineage-specific CDK activity dynamics characterize early mammalian development. Cell Rep. 2025 Apr 22;44(4):115558. doi: 10.1016/j.celrep.2025.115558. Epub 2025 Apr 11. PMCID: PMC12070373. PMID: 40220290 Free PMC article.

Wang Y, Ohnuki H, Tran AD, Wang D, Ha T, Feng JX, Sim M, Barnhill R, Lugassy C, Sargen MR, Salazar-Cavazos E, Kruhlak M, Tosato G. Induced clustering of SHP2-depleted tumor cells in vascular islands restores sensitivity to MEK/ERK inhibition. J Clin Invest. 2025 Mar 25;135(10):e181609. doi: 10.1172/JCI181609. PMCID: PMC12077907. PMID: 40131370 Free PMC article.

Sebastian R, Sun EG, Fedkenheuer M, Fu H, Jung S, Thakur BL, Redon CE, Pegoraro G, Tran AD, Gross JM, Mosavarpour S, Kusi NA, Ray A, Dhall A, Pongor LS, Casellas R, Aladjem MI. Mechanism for local attenuation of DNA replication at double-strand breaks. Nature. 2025 Mar;639(8056):1084-1092. doi: 10.1038/s41586-024-08557-9. PMID: 39972127

Raychaudhuri K, Rangu R, Ma A, Alvinez N, Tran AD, Pallikkuth S, McIntire KM, Garvey JA, Yi J, Samelson LE. CD28 shapes T cell receptor signaling by regulating Lck dynamics and ZAP70 activation. Front Immunol. 2024 Dec 24;15:1503018. doi: 10.3389/fimmu.2024.1503018. PMCID: PMC11703918. PMID: 39776902 Free PMC article.

Kimura T, Kruhlak M, Zhao L, Hwang E, Fozzatti L, Cheng SY. Combinatory actions of cytokines induce M2-like macrophages in anaplastic thyroid cancer. Am J Cancer Res. 2024 Dec 15;14(12):5812-5825. doi: 10.62347/QUWQ3794. PMCID: PMC11711523. PMID: 39803637 Free PMC article.

Ramos-León F, Anjuwon-Foster BR, Anantharaman V, Updegrove TB, Ferreira CN, Ibrahim AM, Tai CH, Kruhlak MJ, Missiakas DM, Camberg JL, Aravind L, Ramamurthi KS. PcdA promotes orthogonal division plane selection in Staphylococcus aureus. Nat Microbiol. 2024 Nov;9(11):2997-3012. doi: 10.1038/s41564-024-01821-8. Epub 2024 Oct 28. PMCID: PMC12323706. PMID: 39468247 Free PMC article.

Hwang E, Kruhlak M, Wong N, Chari R, Kimura T, Cheng SY. Attenuation of aggressive tumor progression of anaplastic thyroid cancer by p53. Am J Cancer Res. 2024 Sep 15;14(9):4429-4444. doi: 10.62347/KXJJ8824. PMCID: PMC11477845. PMID: 39417187 Free PMC article.

Mizunuma M, Redon CE, Saha LK, Tran AD, Dhall A, Sebastian R, Taniyama D, Kruhlak MJ, Reinhold WC, Takebe N, Pommier Y. Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4. Cancer Res Commun. 2024 Aug 1;4(8):2101-2111. doi: 10.1158/2767-9764.CRC-24-0093. PMCID: PMC11322923. PMID: 39041239 Free PMC article.

Balagopalan L, Moreno T, Qin H, Angeles BC, Kondo T, Yi J, McIntire KM, Alvinez N, Pallikkuth S, Lee ME, Yamane H, Tran AD, Youkharibache P, Cachau RE, Taylor N, Samelson LE. Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs. Sci Signal. 2024 Jul 23;17(846):eadp8569. doi: 10.1126/scisignal.adp8569. Epub 2024 Jul 23. PMCID: PMC11389647. PMID: 39042728 Free PMC article.

Silvestri VL, Tran AD, Chung M, Chung N, Gril B, Robinson C, Difilippantonio S, Wei D, Kruhlak MJ, Peer CJ, Figg WD, Khan I, Steeg PS. Distinct uptake and elimination profiles for trastuzumab, human IgG, and biocytin-TMR in experimental HER2+ brain metastases of breast cancer. Neuro Oncol. 2024 Jun 3;26(6):1067-1082. doi: 10.1093/neuonc/noae025. PMCID: PMC11145443. PMID: 38363979 Free PMC article.

Kimura T, Doolittle WKL, Kruhlak M, Zhao L, Hwang E, Zhu X, Tang B, Wolcott KM, Cheng, SY. Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer. Thyroid. 2024 Apr;34(4):484-495. doi: 10.1089/thy.2023.0521. Epub 2024 Jan 16. PMCID: PMC10998707. PMID: 38115586 Free PMC article.

Phelan JD, Scheich S, Choi J, Wright GW, Häupl B, Young RM, Rieke SA, Pape M, Ji Y, Urlaub H, Bolomsky A, Doebele C, Zindel A, Wotapek T, Kasbekar M, Collinge B, Huang DW, Coulibaly ZA, Morris VM, Zhuang X, Enssle JC, Yu X, Xu W, Yang Y, Zhao H, Wang Z, Tran AD, Shoemaker CJ, Shevchenko G, Hodson DJ, Shaffer AL 3rd, Staudt LM, Oellerich T. Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy. Cancer Cell. 2024 Feb 12;42(2):238-252.e9. doi: 10.1016/j.ccell.2023.12.019. Epub 2024 Jan 11. PMCID: PMC11256978. PMID: 38215749 Free PMC article.

Sundara Rajan S, Ebegboni VJ, Pichling P, Ludwig KR, Jones TL, Chari R, Tran A, Kruhlak MJ, Loncarek J, Caplen NJ. Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription. Mol Cell Biol. 2024;44(3):103-122. doi: 10.1080/10985549.2024.2315425. Epub 2024 Mar 20. PMCID: PMC10986767. PMID: 38506112 Free PMC article.

Sala L, Kumar M, Prajapat M, Chandrasekhar S, Cosby RL, La Rocca G, Macfarlan TS, Awasthi P, Chari R, Kruhlak M, Vidigal JA. AGO2 silences mobile transposons in the nucleus of quiescent cells. Nat Struct Mol Biol. 2023 Dec;30(12):1985-1995. doi: 10.1038/s41594-023-01151-z. PMID: 37985687

Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. Genes Dev. 2023 Oct 1;37(19-20):913-928. doi: 10.1101/gad.351085.123. Epub 2023 Nov 6. PMCID: PMC10691471. PMID: 37932011 Free PMC article.

Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM. RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules. Nucleic Acids Res. 2023 Sep 22;51(17):9337-9355. doi: 10.1093/nar/gkad585. PMCID: PMC10516652. PMID: 37427791 Free PMC article.

Liu Z, Kruhlak MJ, Thiele CJ. Zinc finger transcription factor CASZ1b is involved in the DNA damage response in live cells. Biochem Biophys Res Commun. 2023 Jun 30;663:171-178. doi: 10.1016/j.bbrc.2023.04.085. Epub 2023 Apr 25. PMCID: PMC10880029. PMID: 37121127 Free PMC article.

Islam SMR, Maeda T, Tamaoki N, Good ML, Kishton RJ, Paria BC, Yu Z, Bosch-Marce M, Bedanova NM, Liu C, Kruhlak MJ, Restifo NP, Vizcardo R. Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells. Cancer Res Commun. 2023 May 25;3(5):917-932. doi: 10.1158/2767-9764.CRC-22-0265. PMCID: PMC10211394. PMID: 37377887 Free PMC article.

Tamaoki N, Siebert S, Maeda T, Ha NH, Good ML, Huang Y, Vodnala SK, Haro-Mora JJ, Uchida N, Tisdale JF, Sweeney CL, Choi U, Brault J, Koontz S, Malech HL, Yamazaki Y, Isonaka R, Goldstein DS, Kimura M, Takebe T, Zou J, Stroncek DF, Robey PG, Kruhlak MJ, Restifo NP, Vizcardo R. Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells. Cell Rep Methods. 2023 Apr 24;3(4):100460. doi: 10.1016/j.crmeth.2023.100460. PMCID: PMC10163025. PMID: 37159663 Free PMC article.

Malik N, Kim YI, Yan H, Tseng YC, du Bois W, Ayaz G, Tran AD, Vera-Ramirez L, Yang H, Michalowski AM, Kruhlak M, Lee M, Hunter KW, Huang J. Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer. Cancer Res. 2023 Apr 14;83(8):1280-1298. doi: 10.1158/0008-5472.CAN-22-2525. PMCID: PMC10106426. PMID: 36799863 Free PMC article.

Kim M, Kruhlak M, Hoffmann V, Zerfas P, Bishop K, Doolittle WKL, Edmondson EF, Zhu YJ, Cheng SY. Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α. Thyroid. 2023 Feb;33(2):239-250. doi: 10.1089/thy.2022.0336. Epub 2022 Nov 3. PMCID: PMC10081711. PMID: 36103385 Free PMC article.

Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Active DNA demethylation promotes cell fate specification and the DNA damage response. Science. 2022 Dec 2;378(6623):983-989. doi: 10.1126/science.add9838. Epub 2022 Dec 1. PMCID: PMC10196940. PMID: 36454826 Free PMC article.

Clausse V, Zheng H, Amarasekara H, Kruhlak M, Appella DH. Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21. Nucleic Acids Res. 2022 Oct 28;50(19):10839-10856. doi: 10.1093/nar/gkac864. PMCID: PMC9638920. PMID: 36215040 Free PMC article.

Caminear MW, Harrington BS, Kamdar RD, Kruhlak MJ, Annunziata CM. Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells. Front Oncol. 2022 Mar 17;12:762820. doi: 10.3389/fonc.2022.762820. PMCID: PMC8967967. PMID: 35372040 Free PMC article.

Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H, Lee MP, Kruhlak MJ, Dwyer JE, Simpson RM, Hager GL, Ruan Y, Hunter KW. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response. Nat Commun. 2021 Dec 13;12(1):7216. doi: 10.1038/s41467-021-27451-w. PMCID: PMC8669001. PMID: 34903738 Free PMC article.

Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CN, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S. The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner. Sci Adv. 2021 Oct;7(40):eabg8306. doi: 10.1126/sciadv.abg8306. Epub 2021 Oct 1. PMCID: PMC10292047. PMID: 34597136 Free PMC article.

Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S. CTCF is a barrier for 2C-like reprogramming. Nat Commun. 2021 Aug 11;12(1):4856. doi: 10.1038/s41467-021-25072-x. PMCID: PMC8358036. PMID: 34381034 Free PMC article.

Wu AML, Gossa S, Samala R, Chung MA, Gril B, Yang HH, Thorsheim HR, Tran AD, Wei D, Taner E, Isanogle K, Yang Y, Dolan EL, Robinson C, Difilippantonio S, Lee MP, Khan I, Smith QR, McGavern DB, Wakefield LM, Steeg PS. Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis. Clin Cancer Res. 2021 Aug 1;27(15):4422-4434. doi: 10.1158/1078-0432.CCR-21-1549. Epub 2021 Jun 3. PMCID: PMC9974011. PMID: 34083229 Free PMC article.

Wang Y, Salvucci O, Ohnuki H, Tran AD, Ha T, Feng JX, DiPrima M, Kwak H, Wang D, Yu Y, Kruhlak M, Tosato G. Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth. EMBO Mol Med. 2021 Jul 7;13(7):e14089. doi: 10.15252/emmm.202114089. Epub 2021 Jun 8. PMCID: PMC8261520. PMID: 34102002 Free PMC article.

Baik JY, Liu Z, Jiao D, Kwon HJ, Yan J, Kadigamuwa C, Choe M, Lake R, Kruhlak M, Tandon M, Cai Z, Choksi S, Liu ZG. ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer. Nat Commun. 2021 May 11;12(1):2666. doi: 10.1038/s41467-021-23004-3. PMCID: PMC8113527. PMID: 33976222 Free PMC article.

Han CR, Wang H, Hoffmann V, Zerfas P, Kruhlak M, Cheng SY. Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish. Thyroid. 2021 Feb;31(2):315-326. doi: 10.1089/thy.2020.0332. Epub 2020 Sep 25. PMCID: PMC7891307. PMID: 32762296 Free PMC article.

Lita A, Pliss A, Kuzmin A, Yamasaki T, Zhang L, Dowdy T, Burks C, de Val N, Celiku O, Ruiz-Rodado V, Nicoli ER, Kruhlak M, Andresson T, Das S, Yang C, Schmitt R, Herold-Mende C, Gilbert MR, Prasad PN, Larion M. IDH1 mutations induce organelle defects via dysregulated phospholipids. Nat Commun. 2021 Jan 27;12(1):614. doi: 10.1038/s41467-020-20752-6. PMCID: PMC7840755. PMID: 33504762 Free PMC article.

Ahn JI, Park JE, Meng L, Zhang L, Kim TS, Kruhlak MJ, Kim BY, Lee KS. Phase separation of the Cep63•Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes. Cell Cycle. 2020 Dec;19(24):3437-3457. doi: 10.1080/15384101.2020.1843777. Epub 2020 Nov 18. PMCID: PMC7781590. PMID: 33208041 Free PMC article.

Walter B, Gil S, Naizhen X, Kruhlak MJ, Linehan WM, Srinivasan R, Merino MJ. Determination of the Expression of PD-L1 in the Morphologic Spectrum of Renal Cell Carcinoma. J Cancer. 2020 Mar 26;11(12):3596-3603. doi: 10.7150/jca.35738. PMCID: PMC7150459. PMID: 32284756 Free PMC article.

Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Mol Cell. 2020 Jan 2;77(1):26-38.e7. doi: 10.1016/j.molcel.2019.09.024. Epub 2019 Oct 22. PMCID: PMC6993210. PMID: 31653568 Free PMC article.

Sharma NR, Majerciak V, Kruhlak MJ, Yu L, Kang JG, Yang A, Gu S, Fritzler MJ, Zheng ZM. KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. Nucleic Acids Res. 2019 Sep 26;47(17):9368-9385. doi: 10.1093/nar/gkz683. PMCID: PMC6755100. PMID: 31400113 Free PMC article.

Vizcardo R, Rafiqul Islam SM, Maeda T, Tamaoki N, Good ML, Klemen ND, Bosch-Marce M, Jia L, Kruhlak MJ, Restifo NP. A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants. J Vis Exp. 2019 Aug 9;(150):10.3791/58672. doi: 10.3791/58672. PMCID: PMC8191389. PMID: 31449236 Free PMC article.

Kadakia T, Tai X, Kruhlak M, Wisniewski J, Hwang IY, Roy S, Guinter TI, Alag A, Kehrl JH, Zhuang Y, Singer A. E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex. J Exp Med. 2019 Aug 5;216(8):1749-1761. doi: 10.1084/jem.20182285. Epub 2019 Jun 14. PMCID: PMC6683992. PMID: 31201207 Free PMC article.

Vodnala SK, Eil R, Kishton RJ, Sukumar M, Yamamoto TN, Ha NH, Lee PH, Shin M, Patel SJ, Yu Z, Palmer DC, Kruhlak MJ, Liu X, Locasale JW, Huang J, Roychoudhuri R, Finkel T, Klebanoff CA, Restifo NP. T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science. 2019 Mar 29;363(6434):eaau0135. doi: 10.1126/science.aau0135. PMCID: PMC8194369. PMID: 30923193 Free PMC article.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB. Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Mol Cell. 2019 Mar 21;73(6):1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006. Epub 2019 Feb 7. PMCID: PMC6485942. PMID: 30745086 Free PMC article.

Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28. PMCID: PMC6430682. PMID: 30704900 Free PMC article.

Dadashian EL, McAuley EM, Liu D, Shaffer AL 3rd, Young RM, Iyer JR, Kruhlak MJ, Staudt LM, Wiestner A, Herman SEM. TLR Signaling Is Activated in Lymph Node-Resident CLL Cells and Is Only Partially Inhibited by Ibrutinib. Cancer Res. 2019 Jan 15;79(2):360-371. doi: 10.1158/0008-5472.CAN-18-0781. Epub 2018 Nov 29. PMCID: PMC6342512. PMID: 30498085 Free PMC article.