Publications

Mizunuma M, Redon CE, Saha LK, Tran AD, Dhall A, Sebastian R, Taniyama D, Kruhlak MJ, Reinhold WC, Takebe N, Pommier Y. Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4. Cancer Res Commun. 2024 Aug 1;4(8):2101-2111. doi: 10.1158/2767-9764.CRC-24-0093. PMID: 39041239 Free PMC article.

Sundara Rajan S, Ebegboni VJ, Pichling P, Ludwig KR, Jones TL, Chari R, Tran A, Kruhlak MJ, Loncarek J, Caplen NJ. Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription. Mol Cell Biol. 2024;44(3):103-122. doi: 10.1080/10985549.2024.2315425. Epub 2024 Mar 20. PMID: 38506112

Silvestri VL, Tran AD, Chung M, Chung N, Gril B, Robinson C, Difilippantonio S, Wei D, Kruhlak MJ, Peer CJ, Figg WD, Khan I, Steeg PS. Distinct uptake and elimination profiles for trastuzumab, human IgG, and biocytin-TMR in experimental HER2+ brain metastases of breast cancer. Neuro Oncol. 2024 Jun 3;26(6):1067-1082. doi: 10.1093/neuonc/noae025. PMID: 38363979

Kimura T, Doolittle WKL, Kruhlak M, Zhao L, Hwang E, Zhu X, Tang B, Wolcott KM, Cheng SY. Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer. Thyroid. 2024 Apr;34(4):484-495. doi: 10.1089/thy.2023.0521. Epub 2024 Jan 16. PMID: 38115586

Kim M, Kruhlak M, Hoffmann V, Zerfas P, Bishop K, Doolittle WKL, Edmondson EF, Zhu YJ, Cheng SY. Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.  Thyroid. 2023 Feb;33(2):239-250. doi: 10.1089/thy.2022.0336. Epub 2022 Nov 3. PMID: 36103385 Free PMC article.

Malik N, Kim YI, Yan H, Tseng YC, du Bois W, Ayaz G, Tran AD, Vera-Ramirez L, Yang H, Michalowski AM, Kruhlak M, Lee M, Hunter KW, Huang J. Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer.  Cancer Res. 2023 Apr 14;83(8):1280-1298. doi: 10.1158/0008-5472.CAN-22-2525. PMID: 36799863 Free PMC article.

Liu Z, Kruhlak MJ, Thiele CJ. Zinc finger transcription factor CASZ1b is involved in the DNA damage response in live cells.  Biochem Biophys Res Commun. 2023 Jun 30;663:171-178. doi: 10.1016/j.bbrc.2023.04.085. Epub 2023 Apr 25. PMID: 37121127 Free PMC article.

Islam SMR, Maeda T, Tamaoki N, Good ML, Kishton RJ, Paria BC, Yu Z, Bosch-Marce M, Bedanova NM, Liu C, Kruhlak MJ, Restifo NP, Vizcardo R. Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells. Cancer Res Commun. 2023 May 25;3(5):917-932. doi: 10.1158/2767-9764.CRC-22-0265. eCollection 2023 May. PMID: 37377887 Free PMC article.

Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM. RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules. Nucleic Acids Res. 2023 Sep 22;51(17):9337-9355. doi: 10.1093/nar/gkad585. PMID: 37427791 Free PMC article.

Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. Genes Dev. 2023 Oct 1;37(19-20):913-928. doi: 10.1101/gad.351085.123. Epub 2023 Nov 6. PMID: 37932011 Free PMC article.

Sala L, Kumar M, Prajapat M, Chandrasekhar S, Cosby RL, La Rocca G, Macfarlan TS, Awasthi P, Chari R, Kruhlak M, Vidigal JA. AGO2 silences mobile transposons in the nucleus of quiescent cells. Nat Struct Mol Biol. 2023 Dec;30(12):1985-1995. doi: 10.1038/s41594-023-01151-z. Epub 2023 Nov 20. PMID: 37985687

Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Active DNA demethylation promotes cell fate specification and the DNA damage response.  Science. 2022 Dec 2;378(6623):983-989. doi: 10.1126/science.add9838. Epub 2022 Dec 1. PMID: 36454826 Free PMC article.

Olbrich, T., Vega-Sendino, M., Tillo, D., Wu, W., Zolnerowich, N., Pavani, R., Tran, A.D., Domingo, C.N., Franco, M., Markiewicz-Potoczny, M., Pegoraro, G., Fitzgerald, P.C., Kruhlak, M.J., Lazzerini-Denchi, E., Nora, E.P., Nussenzweig, A., Ruiz, S. CTCF is a barrier for 2C-like reprogramming. Nat Commun. 2021 Aug 11;12(1):4856.  doi: 10.1038/s41467-021-25072-x.

Wang, Y., Salvucci, O., Ohnuki, H., Tran, A.D., Ha, T., Feng, J.X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., Tosato, G. Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth. EMBO Mol Med. 2021 Jul 7;13(7):e14089.  doi: 10.15252/emmm.202114089.  Epub 2021 Jun 8.

Baik, J.Y., Liu, Z., Jiao, D., Kwon, H.J., Kadigamuwa, C., Choe, M., Lake, R., Kruhlak, M.J., Tandon, M., Cai, Z., Choksi, S., Liu, Z.G. ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer. Nat Commun. 2021 May 11;12(1):2666.  doi: 10.1038/s41467-021-23004-3.

Lita, A., Pliss, A., Kuzmin, A., Yamasaki, T., Zhang, L., Dowdy, T., Burks, C., de Val, N., Celiku, O., Ruiz-Rodado, V., Nicoli, E.R., Kruhlak, M.J., Andersson, T., Das, S., Yang, C., Schmitt, R., Herold-Mende, C., Gilbert M.R., Prasad, P.N., Larion, M. IDH1 mutations induce organelle defects via dysregulated phospholipids. Nat Commun. 2021 Jan 27;12(1):614.  doi: 10.1038/s41467-020-20752-6.

Han, C.R., Wang, H., Hoffman, V., Zerfas, P., Kruhlak, M.J., Cheng S.Y. Thyroid hormone receptor alpha mutations cause heart defects in zebrafish. Thyroid. 2021 Feb;31(2):315-326.  doi: 10.1089/thy.2020.0332.  Epub 2020 Sep 25.

Ahn, J., Park, J.E., Meng, L., Zhang, L., Kim, T.S. Kruhlak, M.J., Kim, B.Y., Lee, K.S. Phase separation of the Cep63-Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes. Cell Cycle. 2020 Dec;19(24):3437-3457.  doi: 10.1080/15384101.2020.1843777. Epub 2020 Nov 18.

Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H, Lee MP, Kruhlak MJ, Dwyer JE, Simpson RM, Hager GL, Ruan Y, Hunter KW. Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response.  Nat Commun. 2021 Dec 13;12(1):7216. doi: 10.1038/s41467-021-27451-w. PMID: 34903738

Callen, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L.C., Byrum, A.K., Mendez-Dorantes, C., Martinez, P., Canela, A., Maman, Y., Day, A., Kruhlak, M.J., Blasco, M.A., Stark, J.M., Mosammaparast, N., McKinnon, P.J., Nussenzweig, A. 53BP1 enforces distinct pre- and post-resection blocks on homologous recombination. Mol Cell. 2020 Jan 2;77(1):26-38.e7.  doi: 10.1016/j.molcel.2019.09.024.  Epub 2019 Oct 22.

Vodnala, S.K., Eli, R., Kishton, R.J., Sukumar, M., Yamamoto, T.N., Ha, N., Lee, P., Shin, M.H, Patel, S., Yu, Z., Palmer, D., Kruhlak, M.J., Huang, J., Roychoudnuri, R., Finkel, T., Klebanoff, C.A., Restifo, N. P. Dysfunction and stemness of tumor-infiltrating T cells are triggered by a common mechanism. Science. 2019 Mar 29;363(6434):eaau0135.  doi: 10.1126/science.aau0135.