Supported by CCR Office of Science and Technology Resources (OSTR)
CCR Optical Microscopy Cores
Light Microscopy Interest Group
Resources
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Office of Science and Technology Resources

Imaging

Imaging in motion

See the moments static assays miss

Authentic figures and supplementary video from core-supported publications show how intravital microscopy connects cellular behavior to disease biology.

Tumor biology · Figures 6 and 7

Intravital imaging of tumor progression

Select either figure to examine the published imaging data at full size.

Hammoudeh et al., Cell Reports Methods (2024) · Figures 6 and 7
Publication video · Figure 7

Tumor cells circulate in lymphatic vessels

RD-EGFP cells (green) in LYVE-1-labeled lymphatic vessels (red), imaged three days after injection.

Hammoudeh et al., Cell Reports Methods (2024) · CC BY-NC-ND 4.0
Tumor-immune interaction · 2025

TRAIL promotes neutrophil-mediated immune suppression

TRAIL-induced NFkB2 signaling promotes cytokine production, neutrophil chemotaxis, and neutrophil-mediated immune suppression in triple-negative breast cancer.

Kundu M. et al., Cancer Letters (2025)
Therapy response · Figure 4

Response to gene therapy in living muscle

Intravital imaging of GFP-LC3, NAD(P)H, and second-harmonic collagen in treated Pompe disease model mice.

Meena et al., Clinical and Translational Medicine (2024) · CC BY 4.0
Cell fate · Figure 8

Persistent cancer-cell states after CDK2 inhibition

Intravital two-photon microscopy reveals bipolar, multipolar, and multinucleated tumor-cell states in vivo.

Tyutyunyk-Massey et al., JCI Insight (2025) · CC BY 4.0
Signaling and therapy · 2026

Gαs and Hedgehog signaling cross-talk

Dissection of Gαs and Hedgehog signaling cross-talk reveals therapeutic opportunities for targeting Hedgehog-dependent tumors.

Iglesias-Bartolome R. et al., Cancer Research (2026)
Methods primer · Figure 4

Multiphoton intravital microscopy of rodents

A practical overview of multiphoton intravital microscopy methods for visualizing cellular and subcellular behavior in living rodents.

Scheele et al., Nature Reviews Methods Primers (2022)

Figures and video are reproduced from the cited open-access publications. Confirm final institutional and publisher approval before production launch.