Services and Expertise

Collaborative Services

Our team combines advanced microscopy, animal procedures, custom engineering, and quantitative analysis to make ambitious in vivo studies feasible.

01 / Tumor biology

Follow invasion and metastasis in real time

Track tumor initiation, local invasion, intravasation, dissemination, and treatment response within intact microenvironments.

View Figures 6 and 7

02 / Microenvironment

Resolve cells in context

Visualize interactions among cancer cells, immune populations, vasculature, extracellular matrix, and neighboring tissues.

View tumor-cell imaging View TRAIL and neutrophil imaging

03 / Therapeutics

Measure response across scales

Test interventions at tissue, cellular, and subcellular levels with longitudinal imaging of the same living system.

View gene-therapy response View CDK2-inhibition response View Hedgehog therapeutic study

04 / Model development

Adapt IVM to your model

Develop surgical access, orthotopic models, imaging windows, stabilizers, and delivery systems around the biological question.

Meet the team

05 / Advanced methods

Go beyond intensity imaging

Apply FLIM, FRET, FRAP, photoactivation, photoswitching, and second- or third-harmonic generation to measure molecular activity, metabolism, cell dynamics, and tissue structure in vivo.

View multiphoton imaging methods

06 / Analysis

Turn 4D data into evidence

Build reproducible workflows for visualization, segmentation, cell tracking, classification, and quantitative analysis of complex 3D and 4D datasets. Supported approaches include Imaris, AutoQuant, Huygens, FIJI, MATLAB, and validated AI-assisted image-analysis workflows.

Ask about analysis

Expertise

The Core develops longitudinal and terminal imaging methods, including approaches that connect live microscopy with ultrastructure.

Supported tissue types

Longitudinal imaging

Skin, tongue, flexible imaging windows installed on certain tissues

View related publication

Acute imaging

Lymph nodes, mammary gland, spleen, pancreas, liver, bone marrow in tibia or skull, embryo, kidney, and brain.

Preclinical drug studies

IVM complements conventional tumor-growth and endpoint measurements by directly visualizing treatment responses within living tumors. Depending on the model and scientific question, longitudinal imaging can reveal:

Tumor-cell proliferation and death
Changes in tumor vasculature
Immune-cell recruitment and behavior
Local invasion and metastatic dissemination
Persistent or resistant tumor-cell populations