Publications

Yin JJ, Daryanani A, Lu F, Ku AT, Bright JR, Alilin AN, Bowman J, Lake R, Li C, Truong T, Twohig J, Mostaghel EA, Ishikawa M, Simpson RM, Trostel SY, Corey E, Sowalsky AG, Kelly K. Reproducible preclinical models of androgen receptor driven human prostate cancer bone metastasis. Prostate. 2024 Aug;84(11):1033-1046. doi: 10.1002/pros.24718. Epub 2024 May 6.

Beshiri ML, Capaldo BJ, Lake R, Ku AT, Burner D, Tice CM, Tran C, Kostas J, Alilin AN, Yin JJ, Agarwal S, Morris SA, Karzai FH, Lotan TL, Dahut WL, Sowalsky AG, Kelly K. Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer. Stem Cells. 2024 Jun 14;42(6):526-539. doi: 10.1093/stmcls/sxae025.

Agarwal S, Fang L, McGowen K, Yin J, Bowman J, Ku AT, Alilin AN, Corey E, Roudier MP, True LD, Dumpit R, Coleman I, Lee JK, Nelson PS, Capaldo BJ, Mariani A, Hoover C, Senatorov IS, Beshiri M, Sowalsky AG, Hurt EM, Kelly K. Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models. J Clin Invest. 2023 Nov 15;133(22):e162148. doi: 10.1172/JCI162148.

Liu Z, Choksi S, Kwon HJ, Jiao D, Liu C, Liu ZG. Tumor necroptosis-mediated shedding of cell surface proteins promotes metastasis of breast cancer by suppressing anti-tumor immunity. Breast Cancer Res. 2023 Jan 26;25(1):10. doi: 10.1186/s13058-023-01604-9.

Khan I, Gril B, Paranjape AN, Robinson CM, Difilippantonio S, Biernat W, Bieńkowski M, Pęksa R, Duchnowska R, Jassem J, Brastianos PK, Metellus P, Bialecki E, Woodroofe CC, Wu H, Swenson RE, Steeg PS. Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer. Mol Cancer Ther. 2023 May 4;22(5):646-658. doi: 10.1158/1535-7163.MCT-22-0815.

Abel ML, Takahashi N, Peer C, Redon CE, Nichols S, Vilimas R, Lee MJ, Lee S, Shelat M, Kattappuram R, Sciuto L, Pinkiert D, Graham C, Butcher D, Karim B, Sharma AK, Malin J, Kumar R, Schultz CW, Goyal S, Del Rivero J, Krishnamurthy M, Upadhyay D, Schroeder B, Sissung T, Tyagi M, Kim J, Pommier Y, Aladjem M, Raffeld M, Figg WD, Trepel J, Xi L, Desai P, Thomas A. Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial. Clin Cancer Res
. 2023 Sep 15;29(18):3603-3611. doi: 10.1158/1078-0432.CCR-23-0536.

Stuelten CH, Melis N, Subramanian B, Tang Y, Kimicata M, Fisher JP, Weigert R, Zhang YE. Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing. Am J Pathol. 2022 Dec;192(12):1699-1711. doi: 10.1016/j.ajpath.2022.08.002. Epub 2022 Sep 3.

Wong-Rolle A, Dong Q, Zhu Y, Divakar P, Hor JL, Kedei N, Wong M, Tillo D, Conner EA, Rajan A, Schrump DS, Jin C, Germain RN, Zhao C. Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature. J Immunother Cancer. 2022 Jul;10(7):e004698. doi: 10.1136/jitc-2022-004698.

Degorre C, Sutton IC, Lehman SL, Shankavaram UT, Camphausen K, Tofilon PJ. Glioblastoma cells have increased capacity to repair radiation-induced DNA damage after migration to the olfactory bulb. Cancer Cell Int. 2022 Dec 8;22(1):389. doi: 10.1186/s12935-022-02819-0.

Lehman SL, Schwartz KR, Maheshwari S, Camphausen K, Tofilon PJ. CX-5461 induces radiosensitization through modification of the DNA damage response and not inhibition of RNA polymerase I. Sci Rep. 2022 Mar 8;12(1):4059. doi: 10.1038/s41598-022-07928-4.

Bright JR, Lis RT, Ku AT, Terrigino NT, Whitlock NC, Trostel SY, Carrabba NV, Harmon SA, Turkbey B, Wilkinson S, Sowalsky AG. Prostate-Specific Membrane Antigen Is a Biomarker for Residual Disease following Neoadjuvant Intense Androgen Deprivation Therapy in Prostate CancerJ Urol. 2022 Jul;208(1):90-99. doi: 10.1097/JU.0000000000002492. Epub 2022 Mar 1.

Fang L, Li D, Yin J, Pan H, Ye H, Bowman J, Capaldo B, Kelly K. TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence. Cancer Gene Ther. 2022 Oct;29(10):1463-1476. doi: 10.1038/s41417-022-00454-5. Epub 2022 Apr 7.

Sowalsky AG, Figueiredo I, Lis RT, Coleman I, Gurel B, Bogdan D, Yuan W, Russo JW, Bright JR, Whitlock NC, Trostel SY, Ku AT, Patel RA, True LD, Welti J, Jimenez-Vacas JM, Nava Rodrigues D, Riisnaes R, Neeb A, Sprenger CT, Swain A, Wilkinson S, Karzai F, Dahut WL, Balk SP, Corey E, Nelson PS, Haffner MC, Plymate SR, de Bono JS, Sharp A. Assessment of Androgen Receptor splice variant-7 as a biomarker of clinical response in castration-sensitive prostate cancer. Clin Cancer Res. 2022 Aug 15;28(16):3509-3525. doi: 10.1158/1078-0432.CCR-22-0851.

Carlisle JW, Jansen CS, Cardenas MA, Sobierajska E, Reyes AM, Greenwald R, Del Balzo L, Prokhnevska N, Kucuk O, Carthon BC, Mullane PC, Osunkoya A, Baumgarten D, Hosseinzadeh F, Wilkinson S, Lake R, Sowalsky AG, Liu Y, Master VA, Bilen MA, Kissick H. Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood. J Immunother Cancer. 2022 Jul;10(7):e004803. doi: 10.1136/jitc-2022-004803.

Calagua C, Ficial M, Jansen CS, Hirz T, Del Balzo L, Wilkinson S, Lake R, Ku AT, Voznesensky O, Sykes DB, Saylor PJ, Ye H, Signoretti S, Kissick H, Sowalsky AG, Balk SP, Einstein DJ.  A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes. Clin Cancer Res. 2021 Sep 1;27(17):4836-4847. doi: 10.1158/1078-0432.CCR-21-0121. Epub 2021 Jun 24

Baik JY, Liu Z, Jiao D, Kwon HJ, Yan J, Kadigamuwa C, Choe M, Lake R, Kruhlak M, Tandon M, Cai Z, Choksi S, Liu ZG. ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer. Nat Commun 2021 May 11;12(1):2666. doi: 10.1038/s41467-021-23004-3.

Wilkinson S, Ye H, Karzai F, Harmon SA, Terrigino NT, VanderWeele DJ, Bright JR, Atway R, Trostel SY, Carrabba NV, Whitlock NC, Walker SM, Lis RT, Abdul Sater H, Capaldo BJ, Madan RA, Gulley JL, Chun G, Merino MJ, Pinto PA, Salles DC, Kaur HB, Lotan TL, Venzon DJ, Choyke PL, Turkbey B, Dahut WL, Sowalsky AG. Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy. 2021 Dec;80(6):746-757. doi: 10.1016/j.eururo.2021.03.009. Epub 2021 Mar 27.

Paul CD, Hruska A, Staunton JR, Burr HA, Daly KM, Kim J, Jiang N, Tanner K. Probing cellular response to topography in three dimensions. Biomaterials. 197:101-118 (2019).

 Paul CD, Devine A, Bishop K, Xu Q, Wulftange WJ, Burr H, Daly KM, Lewis C, Green DS, Staunton JR, Choksi S, Liu ZG, Sood R, Tanner K. Human macrophages survive and adopt activated genotypes in living zebrafish. Sci Rep. 9(1):1759 (2019).

 Jansson KH, Tucker JB, Stahl LE, Simmons JK, Fuller C, Beshiri ML, Agarwal S, Fang L, Hynes PG, Alilin AN, Lake R, Abbey Y, Cawley J, Tice CM, Yin J, McKnight C, Klummp-Thomas C, Zhang X, Guha R, Hoover S, Simpson RM, Nguyen HM, Corey E, Thomas CJ, Proia DA, Kelly K. High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer. Sci Rep. 8(1):17239 (2019).

Ward Y, Lake R, Faraji F, Tillman H, Yin JJ, Sperger J, Martin PL, Hunter K, Lang J, Kelly K. CD97 on Tumor Cells Binds Platelets and Mediates Bidirectional Signaling to Promote Transendothelial Migration and Metastasis. Cell Rep. 23(3):808-822 (2018).

Pan H, Lu LY, Wang XQ, Li BX, Kelly K, Lin HS. Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN-/-/p53-/- Prostate Cancer Cells In Vitro and Ex Vivo. Chin J Integr Med. 24(2):109-116 (2018).

Beshiri ML, Tice CM, Tran C, Nguyen HM, Sowalsky AG, Agarwal S, Jansson KH, Yang Q, McGowen KM, Yin J, Alilin AN, Karzai FH, Dahut WL, Corey E, Kelly K. A PDX/Organoid Biobank of Advanced Prostate Cancers Captures Genomic and Phenotypic Heterogeneity for Disease Modeling and Therapeutic Screening. Clin Cancer Res. 24(17):4332-4345 (2018).

Pan H, Jansson KH, Beshiri ML, Yin J, Fang L, Agarwal S, Nguyen H, Corey E, Zhang Y, Liu J, Fan H, Lin H, Kelly K. Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer. Oncotarget. 8(44):77181-77 (2017).

Wang T, Hamilla S, Cam M, Aranda-Espinoza H, Mili S. Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration. Nat Commun. 8(1):896 (2017).

 Jackson S, ElAli A, Virgintino D, Gilbert MR. Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer’s disease. Neuro Oncol. 19(9):1173-1182. (2017).

Oyler-Yaniv J, Oyler-Yaniv A, Shakiba M, Min NK, Chen YH, Cheng SY, Krichevsky O, Altan-Bonnet N, Altan-Bonnet G. Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation. Mol Cell. 66(5):635-647 (2017).

Xu, Q, Jitkaew S, Choksi S, Kadigamuwa C, Choe M, Jang J, Liu C, Liu ZG. The cytoplasmic nuclear receptor RARγ controls RIP1 initiated cell death when cIAP activity is inhibited. Nat Commun. 4;8(1):425 (2017).

Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K. Androgen Deprivation Leads to Increased Carbohydrate Metabolism and Hexokinase 2 Mediated Survival in Pten/Tp53 Deficient Prostate Cancer. Oncogene (4):525-533. (2017).

Xu Q, Choksi S, Qu J, Jang J, Choe M, Banfi B, Engelhardt JF, Liu ZG. NADPH oxidases are essential for macrophage differentiation. J Biol Chem. Sep 16;291(38):20030-41 (2016).

Lee RM, Stuelten CH, Parent CA,Losert W. Collective cell migration over long time scales reveals distinct phenotypes. Converg Sci Phys Oncol. Jun;2(2) (2016).

Cai Z, Zhang A, Choksi S, Li T, Zhang X, Liu ZG. Activation of cell surface proteases promotes necroptosis, inflammation, and cell migration. Cell Res. Aug; 26(8): 886–900 (2016).

Staunton JR, Vieira W, Fung KL, Lake R, Devine A, Tanner K. Mechanical properties of the tumor stromal microenvironment probed ex vivo by in situ-calibrated optical trap-based active microrheology. Cell Mol Bioeng. 9(3):398-417 (2016).

Zhang L, Boufraqech M, Lake R, Kebebew E. Carfilzomib potentiates CUDC-101-induced apoptosis in anaplastic thyroid cancer. Oncotarget 10.18632 (2016).

Liu YN, Yin J, Barrett B, Sheppard-Tillman H, Li D, Casey OM, Fang L, Hynes PG, Ameri AH, Kelly K. Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis. Mol Cell Biol 11:1940-51 (2015).

Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K. Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors. Cell Rep 10:2147-58 (2015).

Chang YS, Chen WY, Yin JJ, Tillman HS, Huang J, Liu YN. EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1. Cancer Res 15:3077-86 (2015).

Divi KV, Ward Y, Poirier MC, Olivero OA. Use of Ciliogenesis to Detect Aneugens: The Role of Primary Cilia. Curr Protoc Toxicol 13:1-8 (2015).

Poruchynsky MS, Komlodi-Pasztor E, Trostel S, Wilkerson J, Regairaz M, Pommier Y, Zhang X, Kumar Maity T, Robey R, Burotto M, Sackett D, Guha U, Fojo AT. Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins. Proc Natl Acad Sci 5:1571-6 (2015).

Siu MK, Tsai YC, Chang YS, Yin JJ, Suau F, Chen WY, Liu YN. Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway. Oncogene 36:4767-76 (2015).

Chen WY, Liu SY, Chang YS, Yin JJ, Yeh HL, Mouhieddine TH, Hadadeh O, Abou-Kheir W, Liu YN. MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer. Oncotarget 1:441-57 (2015).