Staff Biographies-Stephen Lockett, Ph.D.

NCI Optical Microscopy Laboratory

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Stephen Lockett

Director, OMAL
Optical Microscopy and Analysis Laboratory

Background

Stephen Lockett received the Ph.D. degree from the Department of Medicine, Birmingham University, England. His research interests include fluorescence microscopy and the development of analysis software for extracting quantitative information from images. He has published over 120 research papers and has received several international awards.

Selected Publications

Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer.  Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):13030-13035. doi: 10.1073/pnas.1709119114. Epub 2017 Oct 27. PMID: 29087320

Graphcut Based 3D Nuclear Segmentation in Optical Microscopy Tissue Images.  Kaustav Nandy, Rama Chellappa and Stephen J Lockett. IEEE Selected Topics in Signal Processing Special Issue on Advanced Signal Processing in Microscopy and Cell Imaging. 2016, Volume: 10, Issue: 1 Pages: 140 – 150, DOI: 10.1109/JSTSP.2015.2505148.

Quantitative Analysis of F-Actin Redistribution In Astrocytoma Cells Treated With Candidate Pharmaceuticals.  Stephen Lockett, Chrissie Verma, Alla Brafman, Prabhakar Gudla, Kaustav Nandy, Yoshihiro Mimaki, Philip L. Fuchs, Joseph Jaja, Karlyne M. Reilly, John Beutler, Thomas J. Turbyville.   Cytometry Part A, 2014 Jun;85(6):512-21.

3D Image Analysis of Thick Breast Cancer Specimens show High Cell-to-Cell Genetic Heterogeneity. Chin K, Ortiz de Solorzano C, Knowles D, Jones A, Chou W, Rodriguez EG, Kuo WL, Ljung BM, Chew K, Myambo K, Miranda M, Krig S, Garbe J, Stampfer M, Yaswen P, Gray JW, Lockett SJ.  Nature Genetics, 36:984-988,2004.