Publications

2024

Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Mizunuma M, Redon CE, Saha LK, Tran AD, Dhall A, Sebastian R, Taniyama D, Kruhlak MJ, Reinhold WC, Takebe N, Pommier Y.

Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription

Sundara Rajan S, Ebegboni VJ, Pichling P, Ludwig KR, Jones TL, Chari R, Tran A, Kruhlak MJ, Loncarek J, Caplen NJ.

Distinct uptake and elimination profiles for trastuzumab, human IgG, and biocytin-TMR in experimental HER2+ brain metastases of breast cancer.

Silvestri VL, Tran AD, Chung M, Chung N, Gril B, Robinson C, Difilippantonio S, Wei D, Kruhlak MJ, Peer CJ, Figg WD, Khan I, Steeg PS.

Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer

Kimura T, Doolittle WKL, Kruhlak M, Zhao L, Hwang E, Zhu X, Tang B, Wolcott KM, Cheng SY.

2023

AGO2 silences mobile transposons in the nucleus of quiescent cells.

Awasthi P, Chari R, Kruhlak M, Vidigal JA.

Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR

Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A.

RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.

Majerciak V, Zhou T, Kruhlak MJ, Zheng ZM.

Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells

Islam SMR, Maeda T, Tamaoki N, Good ML, Kishton RJ, Paria BC, Yu Z, Bosch-Marce M, Bedanova NM, Liu C, Kruhlak MJ, Restifo NP, Vizcardo R.

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells

Tamaoki N, Siebert S, Maeda T, Ha NH, Good ML, Huang Y, Vodnala SK, Haro-Mora JJ, Uchida N, Tisdale JF, Sweeney CL, Choi U, Brault J, Koontz S, Malech HL, Yamazaki Y, Isonaka R, Goldstein DS, Kimura M, Takebe T, Zou J, Stroncek DF, Robey PG, Kruhlak MJ, Restifo NP, Vizcardo R.

Zinc finger transcription factor CASZ1b is involved in the DNA damage response in live cells

Liu Z, Kruhlak MJ, Thiele CJ.

Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer

Malik N, Kim YI, Yan H, Tseng YC, du Bois W, Ayaz G, Tran AD, Vera-Ramirez L, Yang H, Michalowski AM, Kruhlak M, Lee M, Hunter KW, Huang J.

Morphological and Functional Colonic Defects Caused by a Mutated Thyroid Hormone Receptor α.

Kim M, Kruhlak M, Hoffmann V, Zerfas P, Bishop K, Doolittle WKL, Edmondson EF, Zhu YJ, Cheng SY.

CTCF is a barrier for 2C-like reprogramming

Olbrich, T., Vega-Sendino, M., Tillo, D., Wu, W., Zolnerowich, N., Pavani, R., Tran, A.D., Domingo, C.N., Franco, M., Markiewicz-Potoczny, M., Pegoraro, G., Fitzgerald, P.C., Kruhlak, M.J., Lazzerini-Denchi, E., Nora, E.P., Nussenzweig, A., Ruiz, S.

Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth

Wang, Y., Salvucci, O., Ohnuki, H., Tran, A.D., Ha, T., Feng, J.X., DiPrima, M., Kwak, H., Wang, D., Yu, Y., Kruhlak, M., Tosato, G.

ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer

Baik, J.Y., Liu, Z., Jiao, D., Kwon, H.J., Kadigamuwa, C., Choe, M., Lake, R., Kruhlak, M.J., Tandon, M., Cai, Z., Choksi, S., Liu, Z.G.

IDH1 mutations induce organelle defects via dysregulated phospholipids

Lita, A., Pliss, A., Kuzmin, A., Yamasaki, T., Zhang, L., Dowdy, T., Burks, C., de Val, N., Celiku, O., Ruiz-Rodado, V., Nicoli, E.R., Kruhlak, M.J., Andersson, T., Das, S., Yang, C., Schmitt, R., Herold-Mende, C., Gilbert M.R., Prasad, P.N., Larion, M.

Thyroid hormone receptor alpha mutations cause heart defects in zebrafish

Han, C.R., Wang, H., Hoffman, V., Zerfas, P., Kruhlak, M.J., Cheng S.Y

2022

Active DNA demethylation promotes cell fate specification and the DNA damage response.

Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A.

Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21

Clausse V, Zheng H, Amarasekara H, Kruhlak M, Appella DH.

2021

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H, Lee MP, Kruhlak MJ, Dwyer JE, Simpson RM, Hager GL, Ruan Y, Hunter KW.

Phase separation of the Cep63-Cep152 complex underlies the formation of dynamic supramolecular self-assemblies at human centrosomes

Ahn, J., Park, J.E., Meng, L., Zhang, L., Kim, T.S. Kruhlak, M.J., Kim, B.Y., Lee, K.S.

2020

53BP1 enforces distinct pre- and post-resection blocks on homologous recombination

Callen, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L.C., Byrum, A.K., Mendez-Dorantes, C., Martinez, P., Canela, A., Maman, Y., Day, A., Kruhlak, M.J., Blasco, M.A., Stark, J.M., Mosammaparast, N., McKinnon, P.J., Nussenzweig, A.

2019

Dysfunction and stemness of tumor-infiltrating T cells are triggered by a common mechanism

Vodnala, S.K., Eli, R., Kishton, R.J., Sukumar, M., Yamamoto, T.N., Ha, N., Lee, P., Shin, M.H, Patel, S., Yu, Z., Palmer, D., Kruhlak, M.J., Huang, J., Roychoudnuri, R., Finkel, T., Klebanoff, C.A., Restifo, N. P.